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KMID : 0355820150360010037
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Korean Journal of Oral Anatomy
2015 Volume.36 No. 1 p.37 ~ p.43
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Effect of Lactoferrin on Tooth Development in Rats
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Park Hee-Su
Kim Hyun-Jin
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Abstract
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Among numerous studies related to lactoferrin, effect of lactoferrin involved with the bone formation have been recently noted. It was reported that lactoferrin increased the bone mass by enhancing the activity of the osteoblast as well as the proliferation of osteoblast and inhibiting the osteoclastic activity at the same time. In this study, we investigated the effect of lactoferrin during the tooth development in rats. Rats were divided into 3 groups: naked control, water, and lactoferrin. Naked control (NC) was left untouched, whereas the vehicle control group was injected with water that is the same amount with lactoferrin solution. Lactoferrin was injected daily and the dosage increased gradually by 4,6, 12 and 16 l返 per body weight (g) during postnatal 10 days. In the experimental group injected with 4 and 6 江寒， of lactoferrin, there was no significant difference compare to NC or vehicle control. However, more incisor eruption was occurred in the experimental group injected with 12 and 16 P送 of lactoferrin than that of NC or vehicle control. In order to elucidate the role of lactoferrin during the eruptive tooth movement, the further study will be needed.
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KEYWORD
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lactoferrin, bone remodeling, osteoclast, tooth, eruptive movement
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